IMMUNOTHERAPY and ALZHEIMERS/DEMENTIA

I read an interesting article I want to summarize for you where researchers are looking at a new approach to Alzheimer’s disease.  This is just a study so look at it as a possibility for treatment not a cure at this time.  That is how I am seeing it; you may want to do more research.

The Scientists are working on activating the brains immune cells called microglia.   What they expect to happen is to use an antibody to stimulate the microglia and get it to clear the harmful plaques in the brain.  Now this would be wonderful as it not only would work with Alzheimer’s patients but Parkinson and ALS patients as well.

POINTS THEY MADE:

  • Alzheimer’s drugs now currently taken by patients would not be stopped in doing their job of removing plaques.
  • They call these plaques toxic protein clumps that are sticky and build up.
  • Theses sticky plaques set off a chain of events resulting in atrophy of the brain and cognitive decline.
  • This new treatment could possibly help other neurodegenerative diseases.
  • Microglia surround the plaque and create a barrier controlling the spread of damaging proteins.

I believe ongoing research is absolutely necessary as they still have not removed plaques from the brain of humans although research in mice has afforded them an opportunity to continue their work.

 

Neuroscience News

Science Translational Medicine April 3, 2024

#researchdementia#neurodegeneratives#brain changes

 

UNDERSTANDING LONELINESS in DEMENTIA PATIENTS

Understanding Loneliness and Its Impact on the Elderly, Particularly in Dementia Patients

Loneliness, a distressing experience where an individual feels a lack of social connections or companionship, can significantly affect the elderly, especially those suffering from dementia. Emotional loneliness refers to the absence of close, intimate relationships, which can be particularly acute in dementia patients as they lose the ability to maintain meaningful connections due to cognitive decline. This form of loneliness is deeply personal and emotional, distinguished from social loneliness, which relates to a broader network of relationships.

The relationship between loneliness and depression is profound. Loneliness can lead to depression, and conversely, depression can intensify feelings of loneliness, creating a vicious cycle. In dementia patients, this relationship is even more complex. As cognitive abilities deteriorate, the ability to communicate and engage in social interactions diminishes, exacerbating feelings of isolation and leading to heightened depression. This emotional turmoil can worsen cognitive decline, suggesting a bidirectional influence between loneliness and mental health in dementia.

In group social settings, dementia patients often feel less lonely, benefiting from structured interactions and a sense of belonging. These settings can provide a form of companionship that mitigates the acute sense of emotional loneliness. Activities tailored to their cognitive level can foster engagement and a sense of purpose, which are crucial in alleviating loneliness. However, the effectiveness varies depending on the stage of dementia and the individual’s personality and past social habits.

Being alone, both physically and emotionally, can severely impact the mental and physical health of elderly individuals. Physical effects include increased risks of heart disease, high blood pressure, and weakened immune systems. Mentally, loneliness can accelerate cognitive decline, increase anxiety, and lead to severe depression. For dementia patients, these effects are magnified, as their ability to process and cope with loneliness diminishes.

The feeling of loneliness can indeed become a habit, a psychological state where the individual consistently feels isolated regardless of the presence of others. This habitual loneliness can lead to a withdrawal from social interactions, reinforcing the cycle of isolation. In dementia patients, habitual loneliness can result in further cognitive and emotional decline, making it increasingly difficult for caregivers to engage them.

When individuals are profoundly lonely, they may shut down emotionally and socially. This shutdown is a protective mechanism to guard against further emotional pain. In dementia patients, this shutdown can manifest as increased confusion, irritability, and withdrawal from any attempt at social interaction, complicating caregiving efforts.

Recent advances in neuroimaging have shown that loneliness can indeed be seen on brain scans. For instance, brain regions associated with social cognition, like the prefrontal cortex, show altered activity patterns in lonely individuals. In dementia patients, these changes can be more pronounced, correlating with the severity of their cognitive and emotional symptoms.

Dementia patients, including those with Alzheimer’s, may talk to themselves more frequently when they feel lonely. This self-dialogue can serve as a coping mechanism, providing a semblance of social interaction. It reflects their inner need for communication and connection, even if they can no longer effectively engage with others. Caregivers often notice this behavior and interpret it as a sign of the patient’s deep-seated loneliness.

Research on social interaction and its effects on loneliness in dementia patients has shown promising results. Studies indicate that regular, meaningful social engagement can significantly reduce feelings of loneliness and improve quality of life. Interventions such as memory cafes, pet therapy, and structured group activities have been effective in fostering social bonds and reducing loneliness. However, the degree of benefit varies, highlighting the need for personalized approaches in managing loneliness among dementia patients.

 

Alzheimer’s/Dementia Occurrence in Other Countries

Alzheimer’s disease and other forms of dementia are significant health concerns worldwide, including in countries like Mexico, Germany, Japan, Canada, Brazil, Chile, Argentina, Australia, Norway, Belgium, Cuba, and Haiti. The demographics and occurrence of these diseases vary due to differences in aging populations, healthcare systems, and lifestyle factors. In many of these countries, the prevalence of dementia is increasing as populations age, highlighting the need for effective diagnosis, care, and prevention strategies.

In Mexico, the aging population is growing, and with it, the incidence of Alzheimer’s and dementia. Diagnosis is often delayed due to limited awareness and healthcare resources. Families primarily care for patients at home, with limited institutional support available. Similarly, in Haiti, there is a lack of specialized healthcare services for dementia, and care is typically provided by family members. Both countries face challenges in providing adequate care due to economic constraints and limited healthcare infrastructure.

Germany and Japan have well-developed healthcare systems and higher rates of dementia diagnosis due to their older populations. Both countries have extensive institutional care options, including specialized dementia care facilities. In Germany, patients receive comprehensive care through a combination of family support and professional services. Japan, facing one of the world’s highest rates of dementia, has implemented innovative community-based care models to support patients and their families, including day-care centers and home-visit services.

Canada and Australia also experience high prevalence rates of dementia due to their aging demographics. Both countries emphasize early diagnosis and provide robust support systems, including memory clinics and community care programs. Institutional care is available, but there is a strong emphasis on supporting patients in their own homes for as long as possible. Canada has national strategies to address dementia, focusing on research, awareness, and improving the quality of life for those affected.

In Brazil and Argentina, the rising number of dementia cases is a growing public health concern. Diagnosis is often delayed due to healthcare system limitations and socioeconomic factors. Care is primarily provided by families, with limited access to specialized facilities. However, awareness campaigns and efforts to improve healthcare infrastructure are gradually addressing these challenges. Chile faces similar issues but has been making strides in increasing public awareness and providing training for healthcare professionals.

Norway and Belgium have advanced healthcare systems with comprehensive dementia care programs. Norway, with its well-established welfare system, provides extensive support for dementia patients, including home care services and specialized residential facilities. Belgium also offers a range of care options, with a strong emphasis on community-based services and support for caregivers. Both countries have robust data collection on dementia, aiding in the development of targeted interventions.

Cuba, despite economic challenges, provides universal healthcare and has programs in place for early detection and care of dementia. The healthcare system focuses on community-based care, with family doctors playing a key role in managing patients. Conversely, in Haiti, the lack of resources and infrastructure poses significant challenges in diagnosing and caring for dementia patients, resulting in many cases going unreported and untreated.

Environmental factors such as diet, sleep, pollution, accidents, head injuries, altitude, and stroke contribute to the risk of developing dementia in all these countries. For instance, diet and sleep quality are recognized as important factors in brain health, with countries promoting balanced diets and good sleep hygiene as preventative measures. Pollution and head injuries are also significant risk factors, with urban areas and lower-income regions often facing higher risks due to environmental conditions and limited access to healthcare.

Comparing these countries to the United States, where Alzheimer’s and dementia are also major health concerns, we see similarities and differences. The U.S. has extensive research and resources dedicated to understanding and treating these diseases, with a strong emphasis on early diagnosis and a variety of care options ranging from in-home care to specialized facilities. However, disparities in healthcare access and socioeconomic factors still impact the quality of care and outcomes for many patients.

In summary, while the prevalence and management of Alzheimer’s and dementia vary across these countries, common challenges include the need for early diagnosis, adequate care, and addressing environmental risk factors. Countries with more developed healthcare systems tend to provide better support and resources for patients and caregivers, highlighting the importance of healthcare infrastructure in managing these diseases.

Internet Search of Prevalence of Alzheimer’s/Dementia in Other Countries Specifically Requested

 

ALZHEIMER’S/DEMENTIA and ANXIETY

Anxiety, in its essence, is a pervasive feeling of dread and apprehension that can afflict anyone, regardless of age, gender, or background. It’s a complex emotion that can manifest in various forms, ranging from mild unease to crippling panic. Medically and clinically, anxiety is interpreted as a response to perceived threats, whether they are physical, mental, or emotional. This response triggers a cascade of physiological reactions in the body, often involving the nervous system and the release of stress hormones like cortisol.

For many individuals, anxiety presents itself as a combination of physical sensations and psychological distress. The heart may race, breathing may become shallow, and dizziness or feelings of impending doom can arise. These symptoms are not limited to those without dementia; individuals in various stages of Alzheimer’s or dementia can also experience anxiety. However, the interpretation and response to anxiety may differ due to cognitive impairment.

In the context of dementia, anxiety can be particularly distressing. Those experiencing cognitive decline may find it challenging to articulate their feelings or understand what’s happening to them. They might interpret physical sensations as signs of impending danger, such as a heart attack, without being able to express their concerns coherently. This confusion can exacerbate their distress and lead to further cognitive decline if left unaddressed.

The prevalence of anxiety symptoms in individuals with dementia varies depending on the stage of the condition. In the early stages, individuals may still have some awareness of their symptoms and seek help or express their distress to caregivers. However, as dementia progresses, communication becomes more challenging, and symptoms may go unnoticed or misinterpreted by both the individual and their caregivers.

It’s not uncommon for individuals with dementia to have experienced symptoms of anxiety long before their diagnosis. However, the cognitive decline can exacerbate these feelings, leading to more frequent and intense episodes. Imagine waking up in the middle of the night, disoriented and terrified, with no recollection of where you are or why you feel this way. It’s a deeply distressing experience made even more so by the lack of understanding or support from family members who may not fully grasp the extent of their loved one’s suffering.

In such situations, individuals with dementia may find themselves alone, overwhelmed by fear and confusion, unsure of what to do or who to turn to for help. Their cries for assistance may go unheard, leaving them to suffer in silence. It’s a heartbreaking reality that highlights the importance of education and awareness about the psychological and emotional challenges faced by those living with dementia, as well as the need for greater support and empathy from caregivers and society as a whole.

  • Alzheimer’s by Medicine X-USA on Facebook
  •  https://www.alz.org
  • Alzheimer’ Disease Treatments https://www.aarp.org
  • The 36 Hour Day by Nancy L Mace MA & Peter Robins MPH
  • The Changing Brain by Teepa Snow MS OTRL FAOTA
  •  AARP – Dementia Resource Guide
  •  DailyCaring.com
  •  CDC.gov
  •  Medicare.gov
  • Hadley Vlahos RN The In-between Unforgettable Encounters During Lifes                             Final Moments

 

HOW DID I GET HERE? DEMENTIA STOLE THE REAL ME

Being told that I’m in a particular stage of dementia, where memory loss has reached a point where it’s unsafe for me to drive or work, would undoubtedly be a profound and disorienting experience. The realization that my cognitive abilities are declining to the extent that I can no longer perform tasks that were once routine and integral to my identity would be deeply unsettling. Initially, there might be a sense of disbelief or denial, followed by a wave of fear and uncertainty about what the future holds.

As the implications sink in, I imagine there would be a growing sense of isolation and loss. My job, which was not only a source of income but also a significant part of my identity, would suddenly feel out of reach. The inability to carry out basic tasks independently, like shopping or visiting friends, would further exacerbate feelings of loneliness and frustration. Suddenly, the world would feel much smaller, and the once-familiar rhythms of life would become increasingly inaccessible.

Anger would likely become a prevalent emotion as the reality of dementia’s impact on my independence sets in. The loss of autonomy, symbolized by the surrender of my car keys, would be a bitter pill to swallow. The inability to go about daily activities without assistance would feel like a constant reminder of the disease’s relentless progression. It’s easy to see how this frustration could manifest in resentment towards the condition itself, as well as towards those who seem unable to comprehend the magnitude of the loss.

Perhaps one of the most distressing aspects would be the gradual erosion of self-image and confidence. Unable to maintain the same level of grooming and self-care, I would likely start to feel like a stranger to myself. Looking in the mirror would become a sobering experience, as I confront a reflection that no longer aligns with the image, I hold of myself. The disconnect between the vibrant, capable person I once was and the diminished version staring back at me would be a constant source of sadness and confusion.

Ultimately, grappling with dementia would be a journey of profound loss and transformation. The challenge lies in finding ways to navigate this new reality with grace and acceptance, while holding onto fragments of the person I once was. It’s a journey fraught with pain and uncertainty, but perhaps also an opportunity for growth and resilience in the face of adversity.

  • Alzheimer’s by Medicine X-USA on Facebook
  •  https://www.alz.org
  • Alzheimer’ Disease Treatments https://www.aarp.org
  • The 36 Hour Day by Nancy L Mace MA & Peter Robins MPH
  • The Changing Brain by Teepa Snow MS OTRL FAOTA
  •  AARP – Dementia Resource Guide
  •  DailyCaring.com
  •  CDC.gov
  •  Medicare.gov
  • Hadley Vlahos RN The In-between Unforgettable Encounters During Lifes                             Final Moments

 

READING RECOMMENDATIONS

 

  • The 36 HOUR DAY by Nancy Mace & Peter Rabins
  • Learning to Speak Alzheimer’s by Joanne Koenig Coste
  • Creating Moments of Joy Along Alzheimer’s Journey by Jolene Brackey (Audible book)
  • Surviving Alzheimer’s by Paula Spencer Scott
  • Thoughtful Dementia Care Understanding the Dementia Experience by Jennifer Ghent-Fuller
  • Activities To Do with Your Parent Who Has Alzheimer’s/Dementia by Judith Levy
  • Dementia Handbook by Judy Cornish
  • When Reasoning No Longer Works by Angel Smits
  • Understanding the Changing Brain by Teepa Snow